“Raisin” Awareness: A common food you might not have known is potentially toxic to your dog.

It seems a little random, I know, but did you know that grapes (and their dried counterpart, raisins) can be very harmful to dogs? I was surprised to find this out when I first got Leopold (and consequently delved into the world of dog knowledge!).

Grapes contain a toxin that can cause the kidneys to fail in some dogs, which will lead to death if untreated. This does not happen in all dogs and I’ve heard many stories about people who feed their dogs grapes all the time without observable consequences. I imagine that, just like humans, tolerance to certain foods varies from dog to dog. Unfortunately, some dogs have dangerous reactions to consuming grapes and raisins, and this fruit has been known to cause the untimely death of many canines. The risk is high enough that the general advice is to just not give your dog grapes and raisins at all.

What can happen if a dog eats grapes or raisins?
A dog might start to have some gastrointestinal upset including vomiting, diarrhea, and abdominal pain, and in some cases lethargy and depression. Following that, a dog’s kidneys can start to fail (acute renal failure). Renal failure is very serious and will lead to death if left untreated.

Why does this happen?
As someone who is forever interested in the mechanistic components involved in everything, I’ve been looking into what exactly it is about grapes that are bad. Unfortunately, like many topics I research online, information varies. On the boards, I found some that say it’s only the seed (“My vet told me…blah blah blah”), some say it’s the skin. Many published resources say it is an “unknown” toxin. Basically, they just don’t know yet what about the grape causes the problem. What IS known is that sometimes grapes can cause a dog to go into renal failure and die. Personally, I’d rather not take the risk and I don’t ever give my dogs grapes or raisins. The way I see it, there are lots of other yummy treats available (blueberries, for example) that are known to be safe and even healthy. So why risk it?

What should you do if your dog eats grapes or raisins?
Take them to the vet! Right away! I’ve seen more than a few dogs come into the emergency clinic because they ingested raisins or grapes. When we have a dog come in that has eaten grapes or raisins, we generally try to induce vomiting if the grapes/raisins have been eaten within the past few hours. We once had a pair come in that had gotten into some holiday cinnamon-raisin bread (which was particularly disgusting because the cinnamon made the vomit smell delicious. Bleh!). We also sometimes feed the dog a substance that soaks up any toxins that might still be in the dog’s gut, and we monitor blood chemistry to help evaluate kidney function.

Grapes may be a tasty treat for humans, but they’re best left out of your dog’s diet.

Reference:
McKnight, Katrina. (2005). "Grape and Raisin Toxicity in Dogs" (PDF). Veterinary Technician: 135–136. retrieved 06.25.2012

Xylitol toxcity: Some sugar-free chewing gum and foods may be toxic to your dog

I learned something new last week at work that I would like to share. 

We had a dog come in as a toxicity case.  It had consumed xylitol. 

Xylitol?  I had never heard of it.  Which is crazy because it was first identified in 1891 and has started to make an increasing appearance in food and oral care products since the 1970s.  Apparently I just haven’t been paying that close attention to some of my sugar-free foods.

I did some quick research (thanks google!) and found out that I actually consume xylitol on a near daily basis.  Xylitol is a very common sweetener used in chewing gum (and other sugar-free foods such as mints, chewable vitamins, oral-care products, and some baked goods). 

What is xylitol?

Xylitol is a naturally occurring sweetener often used instead of sugar because it has significantly less calories.  It is a part of a group of sweeteners called “sugar alcohols” that also include things like sorbitol, mannitol, glycerol, etc. 

Where is it found in our lives?

Xylitol is increasingly being found in sugar-free snacks and many dental products due to the discovery that xylitol provides some dental health benefits.  Xylitol is in many sugar-free gums, including Orbit, Trident, Dentyne, and many “dental” gums.  Xylitol is also available to buy in a granulated form for baking purposes. 

What does it do to dogs?

Studies have shown that xylitol, while being safe and potentially has health benefits for humans, is toxic to dogs.  It causes a release of insulin; the increase can lead to hypoglycemia (lowered blood sugar levels).  Very high doses of xylitol intake can also potentially lead to liver failure, which can be fatal.

Why does it cause problems in dogs?

Xylitol is absorbed very quickly in dogs; their bodies are fooled into thinking a bunch of sugar just entered the body, so their body reacts by releasing insulin, which helps the body absorb sugar from the blood.  As a result, the blood sugar goes way down—and fast.  It is reported that blood sugars can plummet in only half an hour.

What should you do if you discover your dog ate some xylitol-containing food?

Take it to the vet right away!  Don’t wait for symptoms.  There might be time to induce vomiting and puke up the gum/food.  If the problem is caught early, the dog can be monitored and treated until the problem is gone. 

According to the ASPCA poison control website:

Initial signs of toxicosis include vomiting, lethargy and loss of coordination.  Signs can progress to recumbancy and seizures.  Elevated liver enzymes and liver failure can be seen within a few days.

How much is a toxic dose?

Research suggests that more than 0.1g/kg can lead to hypoglycemia and more than 0.5g/kg can be much worse and lead to liver failure.

That means, for example, that Leopold (who is 31 kg [69lbs]) would have to consume 3.1g of xylitol to be at risk of hypoglycemia, and would have to consume 15.5g of xylitol to be at risk for liver failure. 

In terms of chewing gum (the most likely source in the average home), one source recommends that if your dog ate gum with xylitol listed as the first sugar alcohol ingredient, then base the dose on the total amount of sugar alcohols; this will result in an over-estimation (but better safe than sorry, right?)

If your dog ate gum with xylitol not listed as the first sugar alcohol ingredient, then assume 0.3g of xylitol per piece of gum.  Also, I cup of powdered xylitol = about 190g.

I chew gum on a regular basis, so I'm glad I learned of this information.  I plan on making sure to keep all gum and other xylitol-containing goods well away from my dogs.

References:

Dunayer, Erik K. (December 2006). "New findings on the effects of xylitol ingestion in dogs". Veterinary Medicine 101 (12): 791–797. Retrieved August 20, 2012.

http://www.aspca.org/pet-care/poison-control/people-foods.aspx